Why is monitoring trough levels important for aminoglycosides and what is the typical trough target range?

• A. To maximize antibiotic exposure; trough around 20-25 mcg/mL
• B. To ensure peak concentrations
• C. To monitor liver function tests
• D. To minimize nephrotoxicity and ototoxicity; trough levels kept low (0.5–2 mcg/mL)

Answer: (D)