Which changes should a nurse expect to observe if a client has a therapeutic effect to amlodipine (Norvasc)?

• A. Greater flexibility
• B. Decreased blood pressure
• C. Improved cognition
• D. Decreased pain

Answer: (B)

Amlodipine works by blocking calcium entry into vascular smooth muscle, causing dilation of peripheral arteries. This relaxation reduces systemic vascular resistance, which lowers blood pressure. So, a decreased blood pressure reflects the intended therapeutic effect of this calcium channel blocker. The other options don’t fit because amlodipine doesn’t directly enhance flexibility, cognition, or pain relief. It’s focused on reducing vascular tone to lower blood pressure, and while it can help with angina by improving blood flow, the primary observable therapeutic change discussed here is the drop in blood pressure.