What is the primary action of statins and a major adverse effect to monitor?

• A. Inhibit HMG-CoA reductase, lowering LDL cholesterol; monitor liver enzymes and CK for myopathy; avoid grapefruit juice.
• B. Inhibit cholesterol absorption in intestines; monitor iron levels; avoid dairy.
• C. Increase HDL; monitor uric acid; avoid vitamin C.
• D. Block bile acid resorption; monitor calcium; avoid dairy.

Answer: (A)