What is the antidote for opioid overdose and what key monitoring is required after administration?

• A. Flumazenil; monitor respirations and oxygen saturation.
• B. Protamine sulfate; monitor coagulation.
• C. Vitamin K; monitor INR.
• D. Naloxone; monitor respirations, oxygen saturation, heart rate, blood pressure, and level of consciousness; watch for re-narcotization due to shorter half-life than opioids.

Answer: (D)