Grapefruit juice can affect statin therapy in what way, and what should a patient be advised?

• A. Grapefruit has no effect on statins
• B. Grapefruit can interact with certain statins by inhibiting metabolism via CYP3A4, increasing plasma levels
• C. Grapefruit reduces absorption of statins
• D. Grapefruit increases the metabolism of all statins, lowering levels

Answer: (B)