A nurse should instruct a client taking isophane insulin suspension (NPH) to eat a snack at which of these times?

• A. One-half hour prior to the dose
• B. Immediately after the dose
• C. In the mid-afternoon
• D. Every two hours during the daytime

Answer: (C)

NPH insulin has a delayed but pronounced peak several hours after dosing, which is when the risk of hypoglycemia is highest. If the dose is taken in the morning, the peak typically occurs in the mid to late afternoon. Eating a snack in the mid-afternoon helps prevent low blood glucose during this peak. Snacking half an hour before, immediately after the dose, or every two hours all day does not align with the drug’s peak action and is not necessary.