A nurse should administer theophylline (Slo-Bid) on which basis?

• A. On a pm basis
• B. On an empty stomach
• C. With antacids
• D. Every 4 hours

Answer: (B)

The main idea is that theophylline absorption is affected by whether the stomach is empty, and it has a narrow therapeutic window, so predictable absorption is crucial. Taking theophylline on an empty stomach helps ensure more consistent and faster absorption, leading to stable serum levels and reducing the risk of fluctuations that could cause toxicity or subtherapeutic effect. If taken with food or with antacids, absorption can be delayed or altered, making levels harder to predict. The other options don’t address this absorption issue or the need for predictable drug levels.