A nurse is assessing a client who is taking glyburide (DiaBeta). Which of these manifestations indicates the need for further assessment prior to administering the scheduled dose?

• A. Blurred vision
• B. Elevated blood pressure
• C. Frequent urination
• D. Cool, wet skin

Answer: (D)

Glyburide lowers blood glucose by stimulating the pancreas to release insulin, so giving it when glucose is already low can cause dangerous hypoglycemia. Cool, wet (clammy) skin is a classic sign of hypoglycemia, signaling that you should assess the patient’s glucose level before administering the dose. If glucose is low, hold the dose and treat hypoglycemia as needed.

Blurred vision and frequent urination point more toward hyperglycemia or long-term diabetes effects, and elevated blood pressure isn’t an immediate red flag for withholding this medication.